IL22 and Crohn disease: It has been found that CD14+ DCs can facilitate the conversion from ILC3 to CD127+ ILC1, which may be associated with Crohn's disease displaying a decreased frequency of ILC3s but significantly expanded ILC1s, while CD103+ DCs can accelerate the differentiation of CD127+ ILC1 to ILC3 by producing retinoic acid (RA) and thus promote IL-22 production [77].