Other cases of CVST described in the literature without identifiable risk factors were limited by inability to obtain thorough history [10], or had later identified, albeit less understood, risk factor such as lupus-like anticoagulant [11], elevated plasminogen activator inhibitor 1 (PAI-1) levels [12], remote history of squamous cell carcinoma [13], nephrotic syndrome [14], or even COVID-19 infection [15]. This evidence concerns the gene SERPINE1 and nephrotic syndrome.