PDGFB and neoplasm: This locally aggressive tumor is characterized by distinctive molecular alterations, most commonly involving the COL1A1-PDGFB gene fusion resulting from chromosomal translocation t(17;22)(q22;q13) or supernumerary ring chromosomes, which leads to constitutive upregulation of platelet-derived growth factor beta (PDGFB) expression and continuous autocrine activation of platelet-derived growth factor receptor (PDGFR) B [3].