When medication is necessary, options are weighed for orthostatic/anticholinergic risk (e.g., very-low-dose doxepin with orthostatic caution; trazodone with reported orthostatic hypotension; mirtazapine with sedation/rare orthostatic hypotension; orexin antagonists with generally modest hemodynamic impact but potential daytime somnolence) [20]. The gene discussed is HCRT; the disease is hypotensive disorder.