HP and thrombotic thrombocytopenic purpura: When evaluating for TTP in patients with systemic lupus, assessments include a complete blood count (CBC), a comprehensive metabolic panel, urinalysis with urine protein quantification, a reticulocyte count, LDH levels, haptoglobin measurement, a direct Coombs test, a coagulation profile, and a peripheral blood smear [1,4].