Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE), STING-Associated Vasculopathy with Onset in Infancy (SAVI), Aicardi–Goutières syndrome (AGS), and certain monogenic forms of systemic lupus erythematosus (monoSLE) represent key examples of type I interferon–driven disorders. This evidence concerns the gene STING1 and systemic lupus erythematosus.