Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE), STING-Associated Vasculopathy with Onset in Infancy (SAVI), Aicardi–Goutières syndrome (AGS), and certain monogenic forms of systemic lupus erythematosus (monoSLE) represent key examples of type I interferon–driven disorders. The gene discussed is STING1; the disease is vascular disorder.