Because Nrxn3 has been implicated in having a role in social behavior and learning (Dabrowski et al., 2024, Kamal et al., 2023), metabolic regulation (Mu et al., 2024), and obesity/addiction (Bille et al., 2011, Hotta et al., 2010, Lindholm and Schultz-Moller, 1973, Prats-Puig et al., 2013) targeting this gene could result in side effects. The gene discussed is NRXN3; the disease is obesity due to melanocortin 4 receptor deficiency.