Mutations in the genetic sequence responsible for encoding the Nephrin (NPHS1) have been identified as causative factors in aspectrum of renal disorders, resulting in a myriad of pathological conditions affecting the functionality and structure of the kidneys.These genetic variations can give rise to a diverse array of kidney diseases, encompassing a range of manifestations and clinicalpresentations that impact renal function and overall health. Here, NPHS1 is linked to kidney disorder.