Nephrin is a product of the NPHS1 gene, expressed in glomerulus; whose expressionwas identified in 1998 by Kestila and colleagues in congenital Nephrotic syndrome of Finnish population [13].Therefore, it is of interest to review Urinary nephrin as an emerging biomarker in early detection of diabetic nephropathy. Here, NPHS1 is linked to familial nephrotic syndrome.