A study by Sol Kang et al. reported a higher prevalence of obesity in girls with early menarche,with the likelihood of obesity being 1.85 times greater among those who attained menarche before age 12 [17].This link is attributed to elevated plasma estradiol levels and reduced sex hormone-binding globulin (SHBG) levels during puberty,which promote adiposity [38]. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.