To investigate the impact of SERCA2 dysfunction on desmosomal integrity, we analysed the localisation of desmosomal proteins desmoglein 3 (DSG3), desmocollin 3 (DSC3) and desmoplakin (DPK) in 2D cultures of keratinocytes from HD treated or not with TG, and DD patients using confocal microscopy (Figure 1B). This evidence concerns the gene DSG3 and dentin dysplasia.