To investigate the impact of SERCA2 dysfunction on desmosomal integrity, we analysed the localisation of desmosomal proteins desmoglein 3 (DSG3), desmocollin 3 (DSC3) and desmoplakin (DPK) in 2D cultures of keratinocytes from HD treated or not with TG, and DD patients using confocal microscopy (Figure 1B). Here, DSP is linked to Huntington disease.