Tricò et al. demonstrated that incorporating the three major single nucleotide polymorphisms (SNPs) associated with NAFLD, including rs738409 in the PNPLA3 gene, rs1260326 in the GCKR gene, and rs58542926 in the TM6SF2 gene, significantly enhances the predictive capacity for changes in hepatic fat fraction during follow-up assessments [37]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.