Upon excluding the APOE e4 allele (i.e. rs429358_C) from the PRSAD and repeating the association analysis, none of the previously significant associations retained their significance (although nominal significance was observed for several phenotypes, such as Alzheimer’s disease (P = 0.0009), dementias (P = 0.0002), and senile dementia (P = 0.005)) (Suppl. This evidence concerns the gene APOE and Alzheimer disease.