Importantly, angiotensin II (Ang II), a molecule that promotes inflammation, oxidative stress, vascular injury, fatty liver and insulin resistance (Mastoor et al. 2022), has been shown to be able to increase serum FGF21 levels and hepatic Fgf21 gene expression, possibly as a compensatory and protective response against these harmful effects induced by Ang II (Pan et al. 2018; Li et al. 2019). The gene discussed is AGT; the disease is Insulin resistance.