SCD and hypertriglyceridemia: To elucidate the underlying mechanisms of this sugar-induced hypertriglyceridemia, and considering the well-established role of fructose in stimulating lipogenesis and inhibiting β-oxidation, we assessed the hepatic expression of key genes involved in fatty acid metabolism, specifically the lipogenic gene stearoyl-CoA desaturase-1 (Scd1) and the catabolic gene carnitine palmitoyl transferase 1 (Cpt1) (Tappy and Lê 2010).