APOE and cardiovascular disorder: In addition, we have performed the multivariable-adjusted analysis including demographic, lifestyle, and health-related factors-namely, age, sex, education level, systolic blood pressure, use of antihypertensive medication, diabetes mellitus, serum total cholesterol, use of lipid-modifying medication, history of cardiovascular disease, BMI < 18.5 kg/m2, ADL disability, IADL disability, smoking habit, alcohol intake, regular exercise, handgrip strength, depressive symptoms, and APOE-ε4 carrier as covariates (Table 4).