In IDH-wt astrocytoma, resection significantly prolonged PFS (mean 12.8 ± 10.6 months, HR: 0.605, 95%CI 0.333–1.06, p = 0.0296) and OS (mean 26.98 ± 10.6 months, HR: 0.162, 95%CI 0.088–0.2, p < 0.0001) compared to biopsy. Here, IDH1 is linked to astrocytoma (excluding glioblastoma).