In IDH-wt glioblastoma response to alkylating chemotherapy is better in tumors with methylated MGMT promoter [29 P]romoter methylation is detected in about 40% of all patients with IDH-wt astrocytomas and IDH-wt glioblastomas [30, 31]. The gene discussed is MGMT; the disease is astrocytoma (excluding glioblastoma).