IDH2 and astrocytoma (excluding glioblastoma): MGMT methylation was not associated with longer survival in IDH-wt astrocytoma (HR: 0.909 (0.511–1.619), p = 0.2124) but is associated with a favorable therapy response in IDH-wt glioblastoma (HR: 0.694 (0.512–0.939), p = 0.0142) (Fig. 4) (Table 2).