TAC1 and cancer: Despite advances in cancer treatment, chemotherapy remains a cornerstone for many cancers.[1] However, chemotherapy-induced nausea and vomiting (CINV) persists as a common and distressing adverse reaction.[2] Mechanisms include chemotherapy-generated free radicals triggering serotonin (via 5-HT3) and substance P (via NK-1) pathways, driving peripheral/central vomiting.