Chronic granulomatous disease (CGD) is a rare primary hereditary immunodeficiency disorder, with an incidence of approximately 1 in 2,00,000.[1,2] Over 60% of CGD cases are X-linked (X-CGD), which primarily results from mutations in the CYBB gene encoding the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit.[3] Notably, X-CGD has a unique susceptibility to both nontuberculous mycobacterial (NTM) and fungal infections, which are less commonly observed in other immunodeficiencies. Here, CYBB is linked to chronic granulomatous disease.