FMO5 and systemic lupus erythematosus: Additional findings in children with X-CGD may include growth retardation, anemia, thrombocytosis, and other nonspecific signs.[17] Some patients also present with autoimmune phenomena such as systemic lupus erythematosus or inflammatory bowel disease, and these phenomena are likely related to immune dysregulation from impaired NADPH oxidase function.[18] Disease severity often correlates with residual NADPH oxidase activity, and patients with partial activity may exhibit milder phenotypes.[19]