Moreover, studies have shown that the upregulation expression of OSBPL3 in the liver was also observed in the fatty livers of ob/ob mice with type 2 diabetes, db/db mice with a leptin receptor mutation, and alcohol-fed mice.[24,25] These studies are consistent with our findings of OSBPL3 expression trends. The gene discussed is OSBPL3; the disease is type 2 diabetes mellitus.