IgA nephropathy (IgAN) is characterized by recurrent hematuria and IgA deposition in the glomerular mesangium, often exacerbated by upper respiratory tract infections.[1] It is characterized by mesangial IgA deposits, leading to glomerulonephritis and potential kidney dysfunction.[2] While most cases of IgA nephropathy are idiopathic, secondary causes can include viral infections, chronic liver disease, and other systemic conditions.[3] The association between hepatitis E infection and IgA nephropathy is not widely reported, making this case of particular interest. The gene discussed is CD79A; the disease is Recurrent upper respiratory tract infections.