Obesity and MetS are known risk factors for MAFLD.[17,18] MAFLD and psoriasis share the specific pro-inflammatory mediators interleukin-6 (IL-6), TNF, and C-reactive protein (CRP),[8] the production of pro-inflammatory adipocytokines can also contribute to the accumulation of triglycerides, leading to fatty liver disease.[19] Thus, patients with psoriasis may have a linked pathogenesis to MAFLD. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.