Regarding anxiety outcome, both Vedamurthachar et al and Li et al assessed this outcome but used different scales.[11,12] Vedamurthachar et al employed cortisol levels and ACTH, demonstrating a reduction in both arms, with a more pronounced effect in the SKY group.[11] In China, Li et al studied a group of heroin addicts and evaluated the effectiveness of qigong therapy in heroin detoxification. This evidence concerns the gene POMC and Anxiety.