Mechanistic studies have revealed that the deubiquitinase JOSD2 stabilizes HSP90AB1 through deubiquitination, thereby activating oncogenic signaling pathways such as MAPK/ERK and PI3K/AKT, ultimately promoting tumor proliferation, migration, and drug resistance.[12] Meanwhile, HSP90AA1 also plays a crucial role in ESCA. The gene discussed is AKT1; the disease is neoplasm.