HSP90AB1 and cancer: Previous studies have also demonstrated that BPA can modulate the expression or activity of the 2 heat shock proteins HSP90AA1[38,39] and HSP90AB1.[40] HSP90AB1 is overexpressed in multiple cancers and promotes tumor cell proliferation, invasion, and drug resistance by stabilizing oncoproteins, enhancing angiogenesis, and regulating telomerase activity and key signaling pathways, thereby representing a potential therapeutic target.[41] In ESCA, HSP90AB1 has been incorporated into autophagy-related prognostic gene models,[14] suggesting that it may serve as a potential prognostic biomarker.