Ultrastructural studies have shown evidence of keratinocyte and melanocyte damage, characterized by intracellular edema and intracytoplasmic vacuolar degeneration.[2] These lesions are often seen alongside active vitiligo patches such as trichrome or hypochromic lesions.[5] Histopathological examination typically reveals a lymphocytic infiltrate dominated by CD8 + T cells at the dermoepidermal junction, which directly contributes to melanocyte destruction.[4,5]. This evidence concerns the gene CD8A and vitiligo.