CXCL5 and cancer: For example, the expression of COL3A1, a gene crucial to cartilage function, has been discovered in association with the radiographic level of osteoarthritis (OA).[25] According to research, COL3A1 may be an important gene signature that interacts with extracellular matrix receptors and promotes focal adhesion, which may contribute to the development of osteoarthritis.[26] CXCL5 and 6 are 2 of the main members of the CXC subfamily of chemokines, which are related to the invasion and migration of various cancers.