BCL2 and rheumatoid arthritis: Studies have also shown that CXCL6 expression is raised in RA patients, and it may be involved in neutrophil migration and angiogenesis.[27] Studies have suggested that IL-17-mediated articular angiogenesis may be due in part to CXCL5 induction.[28] BCL2A1 is an antiapoptotic BCL2 family member that does not affect cell cycle progression.