INS and type 2 diabetes mellitus: The main causes of lipid abnormalities in T1DM are inadequate insulin production and poor glycemic control.[8] On the other hand, central obesity, hypertension, and insulin resistance are major contributors to metabolic syndrome and T2DM-associated dyslipidemia.[13] With T2DM, the lipid profile is usually more atherogenic, which raises the risk of cardiovascular events.