In 2018, Wanli et al evaluated the relationship between preoperative serum leptin levels and the incidence of postoperative venous thromboembolism in patients with osteoarthritis (OA) undergoing total knee arthroplasty in their hospital.[7] The results showed that high preoperative leptin levels may be an independent risk factor for postoperative DVT. The gene discussed is LEP; the disease is venous thromboembolism.