On the other hand, multiple studies have shown that the protein expression of S6K1 is upregulated in breast cancer [8,9,28,29], although there are some studies that report a positive impact of the expression of phosphorylated S6K1 on survival [30,31], which was specifically shown in breast cancer, in contrast to other types of cancer [32]. This evidence concerns the gene RPS6KB1 and breast carcinoma.