Among these, four key genes, including Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB), Succinate Dehydrogenase Complex Subunit D (SDHD), ATP Synthase F1 Subunit Alpha (ATP5F1A), and ATP Synthase F1 Subunit Beta (ATP5F1B), were downregulated and represent core components of mitochondrial respiratory chain complexes suggesting that impaired mitochondrial function constitutes a shared pathological mechanism linking sarcopenia and obesity [114]. Here, ATP5F1B is linked to obesity due to melanocortin 4 receptor deficiency.