In our chRCC cohort, we observed a high frequency of co-occurring mutations in TP53 and PTEN (n = 19, 31.1%, p < 0.001), TSC2 and FAT1 (n = 2, 40.0%, p = 0.001), and PTEN and KMT2D (n = 3, 13.6%, p = 0.004). This evidence concerns the gene TSC2 and chromophobe renal cell carcinoma.