As stimulation of the FP receptor by PGF2α triggers the initiation of the MAPK pathway, leading to the activation of ERK1/2 and subsequent activation of different pro-inflammatory transcription factors like NF-κB, it is tempting to speculate that FP activation might contribute to tumor growth, development, cell proliferation and metastasis formation in general [223,224]. Here, PTGFR is linked to neoplasm.