RNF126 and cancer: Mechanistically, RNF126 promotes progression of OC by functioning as an E3 ubiquitin ligase that targets ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2 (ACAP2) for proteasomal degradation, thereby reprogramming lipid metabolism and enhancing cancer cell proliferation, invasion, and migration both in vitro and in vivo [17].