TOP2A and infection: The simultaneous overexpression of Klf6, Birc5, Top2a, Pclaf, Ankrd1, and Emp1 (Table 4) suggest that the organoid, in response to the parasite, is undergoing stress, damage, or tissue remodeling, with the hepatic 3D structure attempting to resist or contain the infection through cell proliferation, inhibition of apoptosis, and mechanisms of regeneration or fibrosis.