Further, tissue injury, activation of primary sensory neurons by noxious stimuli and peripheral neuropathy up-regulate MSK1-dependent expression of the epigenetic tag phosphorylated (p) serine 10 (S10) of histone 3 (H3; p-S10H3) in the SSDH [11,12,13,17,18]. This evidence concerns the gene RPS6KA5 and peripheral neuropathy.