MSK1 plays a relevant role in nociceptive signal processing in the SSDH; for example, formalin injection into the mouse hind paw, as well as peripheral neuropathy, activates MSK1 in a group of SSDH cells, and an intrathecally applied MSK1 inhibitor has attenuated pain behavior in both pain models [11,13]. Here, RPS6KA5 is linked to peripheral neuropathy.