ER-low and PD-L1+ patients showed a pCR rate difference of 24.3% in contrast to ER > 10% and PD-L1+ patients at 9.2%; Similarly, TILs ≥ 30% correlates with better EFS outcome for ER-low BC, but not for ER > 10% BC [69]. Here, CD274 is linked to breast cancer.