Our research group reported that Serpin family A member 3 (SERPINA3) and Lipocalin2 (LCN2), which are upregulated in PCa and modulated by osteoblast-derived EVs, regulate PCa cell proliferation and invasion in a tumor-suppressive manner, supported by in vitro and in vivo models [79]. The gene discussed is LCN2; the disease is neoplasm.