Osteoclast-derived EVs carrying miR-21 and miR-214-3p can be directly transferred to prostate cancer cells, where they promote EMT, migration, and therapy resistance through modulation of Phosphatase and Tensin Homolog (PTEN)/AKT serine/threonine kinase 1 (AKT) signaling, supported by in vitro studies [81,82] (Figure 2). Here, PTEN is linked to Familial prostate cancer.