Figure 8 shows serum insulin levels at 0, 6, and 12 weeks after MLE administration. MLE administration in the T2DM-MLE group for six weeks significantly reduced serum insulin levels compared with the T2DM group (9.02 ± 0.24 vs. 12.10 ± 0.41 mU/L, p < 0.001), and this reduction persisted through week 12 (6.70 ± 0.35 mU/L). After 12 weeks, the HOMA-IR index in the T2DM-MLE group was significantly lower than that in the untreated T2DM group (3.71 ± 0.33 vs. 10.68 ± 0.75, p < 0.001, respectively) (Table 3). Here, INS is linked to type 2 diabetes mellitus.