Elevated levels of inflammatory cytokines, such as IL-6, TNF-α, and CRP, were also observed in comorbidities related to the development of sarcopenia, such as T2DM, obesity, mitochondrial dysfunction, and metabolic alterations, confirming the current state of occurrence in the scenario evaluated, in addition to establishing common pathways for its pathological origin. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.