Among the statistically significant genes associated with xenobiotic biotransformation, AKR7A2 may metabolize acrolein and aflatoxins, and many other genes mentioned in the study are encoding enzymes involved in the biotransformation of compounds, such as leukotrienes, glutathione, lipids, retinol, glucose, vitamins B5 and B7, lipoate, and iodide; as well as transports of amino acids, nucleotides, and others, indicating that the development of CRC at the tumor site is associated with the disruption of the biotransformation process. The gene discussed is AKR7A2; the disease is colorectal carcinoma.