Among downregulated differentially expressed genes taking part in the second phase of biotransformation, our results confirm their participation in CRC, namely, GSTM1 [60], GSTM2 [60,66], GSTM4 [66], UGDH [67], UGP2 [68], UGT1A9, and UGT2B17. The gene discussed is GSTM4; the disease is colorectal carcinoma.