Five genes harboring missense variants (ATN1, IFT172, MYH3, NXN, and RYR1) had previously been associated with syndromic forms of clefts, and 13 (EFNB2, EXT1, HAND1, IFT172, KRT17, MEN1, NCOR2, NXN, ROBO1, RPGRIP1L, RYR1, SLC32A1, and TP53BP2) were reported to cause orofacial clefts in knockout mouse models. The gene discussed is RYR1; the disease is orofacial cleft.