Building on our previous findings that demonstrated PTN overexpression in RRMS patients relative to HCS [14], the present study aims to investigate the PTN signaling axis in greater mechanistic detail by examining the expression of its principal receptors (PTPRZ, ALK, SDC3, and ITGB3) in PBMCs. Here, ITGB3 is linked to relapsing-remitting multiple sclerosis.