Although injection of Aβ in wild-type mice does not induce the formation of NFT, the injection of Aβ in mutant-MAPT Tg mice (which develop NFTs) increases the formation of tau aggregates [52] and crossing APP mice with mutant MAPT-Tg mice also greatly increases the formation of tau aggregates [53,54]. Here, MAPT is linked to Neurofibrillary tangles.