STAT3 and neoplasm: Some studies report tumor-promoting effects via ROS generation, AKT/mTOR and STAT3 pathway activation, and tNOX upregulation (at 100 μM for SW480 and CT-26 cell lines and at 12.5 μM for HCT116 cell line) [160], while others demonstrate its antitumor action via PPARγ activation [161], ROS-mediated mitochondrial disruption [162], nitric oxide induction (100 μM of capsaicin and/or 50 μM of resveratrol) [163], and p53 stabilization [164].