IGHE and anaphylaxis: Diagnosing these adverse allergic reactions, which can be either Type I (IgE-mediated) immediate hypersensitivity (e.g., anaphylaxis from honey or royal jelly) or Type IV (T-cell-mediated) delayed hypersensitivity (e.g., contact dermatitis from propolis), requires a tailored approach starting with clinical history, skin-prick tests (SPT), and specific IgE (sIgE) measurement.