AIPL1 and Leber congenital amaurosis: TPR consensus residues required for the antiparallel packing of adjacent α-helices in the TPR motifs and residues involved in tight electrostatic interactions with the C-terminal MEEVD TPR acceptor sites of HSP90 are conserved in AIPL1, which is highlighted by its disruption by LCA-associated mutations, which significantly impair its interaction with HSP90 [18,29,31].