This is consistent with the fact that in humans, mutations in AIPL1 cause severe blindness that affects both rods and cones [87], whereas deficiencies in catalytic rod PDE6 subunits cause RP, primarily a rod disease [101,102], and deficiencies in cone PDE6α′ cause recessive cone dystrophy, and early-onset recessive complete and incomplete achromatopsia [103]. Here, AIPL1 is linked to retinitis pigmentosa 1.