Alterations of HSPA8 activity have been linked to both neurodegenerative and neuropsychiatric diseases, such as neuroaxonal dystrophy, schizophrenia, Parkinson’s and ALS [64,65,66,67], with both HSPA1A and HSPA8 associated with neuroprotection. The gene discussed is HSPA8; the disease is amyotrophic lateral sclerosis.