The proteins may bind to either the extracellular domain via C-type lectin-like receptor-2 (CLEC-2) (described in stroke, brain injury, and tumors), heat shock protein A9 (HSPA9) (postulated in oncological disease including metastatic spread), or chemokine ligands (CCL21) (in cancer invasion) [4,5,6,7]. Here, CLEC1B is linked to Stroke.