Signalling molecules within the melanoma tumour microenvironment, such as those involving the MAPK, PI3K/AKT, and Wnt pathways, can profoundly influence tumour behaviour and melanoma cells actively manipulate these pathways to remodel their microenvironment, promoting angiogenesis, sustaining growth, and evading immune detection [14]. This evidence concerns the gene AKT1 and neoplasm.