At the same time, many of the key miRNAs we report (miR-106a, miR-145, miR-20a, miR-16, miR-101) are also known players in CRC biology, acting on apoptosis, autophagy, epithelial plasticity, and JAK–STAT/NF-κB pathways. The gene discussed is SOAT1; the disease is colorectal carcinoma.