MTHFR and Hyperglycemia: The polymorphic variant C677T in the MTHFR gene is associated with an increased risk of developing type 2 diabetes in the Asian population [87], and the combination of the polymorphic variant 1298AA with hypermethylation of MTHFR has been observed in patients with hyperglycemia and elevated levels of total cholesterol and LDL cholesterol [88].