RUNX1 and acute lymphoblastic leukemia: In fact, the RP mRNA subtype was an independent prognostic factor in B-ALL, independent of the age at diagnosis and presence of traditionally good prognostic markers (ETV6-RUNX1 fusion [12], high hyperdiploidy [10], and trisomy of chromosomes 4 and 10 [11]), as well as presence of minimum residual disease on day 29 of induction therapy.