Consistently, even among B-ALL cases that had traditionally good prognostic markers (i.e., high hyperdiploidy, trisomy of chromosomes 4 and 10, and ETV6-RUNX1 fusion), cluster alpha (N = 43) had significantly shorter (p = 0.035) event-free survival (Figure S5C) than cluster beta (N = 5). The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.