Surprisingly, cluster alpha of B-ALL had worse prognosis than cluster beta despite being significantly more enriched in high hyperdiploidy (29/158 = 18.4% vs. 4/65 = 6.2%, p = 0.022) and trisomy of chromosomes 4 and 10 (17/138 = 12.3% vs. 2/64 = 3.1%, p = 0.040), and considerably more enriched in ETV6-RUNX1 fusion (12/130 = 9.2% vs. 1/62 = 1.6%, p = 0.064). This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.